Epidermolysis bullosa (EB) was diagnosed in eight calves from four farms in the United Kingdom on the basis of clinical, histological and ultrastructural findings. In three affected herds, pedigree Simmental bulls had been mated with Simmental-cross cows. In a fourth herd two Holstein-Friesian calves were affected.
- A congenital bovine epidermolysis resembling epidermolysis bullosa simplex of man (Veterinary Record)
- A mutation in bovine keratin 5 causing epidermolysis bullosa simplex, transmitted by a mosaic sire (PubMed)
Epidermolysis bullosa
a hereditary disease of humans, Collie dogs, Shetland sheepdogs, Suffolk, South Dorset Down and Scottish blackface sheep, and Simmental and Brangus calves. Characterized by epidermal bullae, particularly on areas of pressure or trauma and in sheep in the mouth and on woolless skin. There may be shedding of hooves and horns. Called also red foot disease.
Congenital bovine epidermolysis
ulcers on lips, gums, tongue, muzzle and limb extremities at birth; skin lesions may be local alopecia without ulceration; resembles epidermolysus bullosa simplex in humans; an autosomal dominant recorded in Simmentals.
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